Senior Director, Program Management

Atrium is a biopharmaceutical company pioneering delivery of RNA therapeutics to the heart to transform the standard of care for people living with cardiomyopathies. The Senior Director, Program Management will provide strategic and operational leadership for Atrium's cross-functional drug development programs, with a primary focus on partnering with the Early Development Lead and functional leaders to shape program strategy and drive integrated execution from early development through key clinical and regulatory milestones. As an AI-forward organization, Atrium expects this leader to actively lean into AI-enabled tools and ways of working.

Responsibilities

Lead integrated program management for one or more cross-functional development programs, translating program strategy into executable plans; Own the development and maintenance of integrated development plans in partnership with the program lead, functional leaders, and subject matter experts; Be a role model: build high-performing teams, provide feedback and mentorship, and model corporate culture behaviors; Internally and externally communicate a shared, bold vision for the program and build a patient-centric program; Drive cross-functional team effectiveness through clear governance, meeting cadence, decision logs, action tracking, and escalation pathways; Identify, assess, and communicate program risks, assumptions, dependencies, and bottlenecks; make and recommend trade-offs and develop mitigation plans; Shape executive-level program updates, governance materials, portfolio review inputs, and decision recommendations; Drive program-level budget, resource, and prioritization recommendations in partnership with Finance; Apply program management best practices, tools, and continuous improvement approaches; Build trusted relationships across internal teams and external partners; Mentor and support less experienced program management team members

Requirements

Bachelor's degree in a life sciences, engineering, business, or related discipline; 12+ years of biotechnology or pharmaceutical industry experience, including 5+ years of experience in drug development program management or integrated project leadership; Strong understanding of the end-to-end drug development process, including nonclinical, translational, clinical, regulatory, CMC, quality, and operational workstreams; Demonstrated success leading cross-functional teams in a matrixed environment, influencing without direct authority, and aligning senior stakeholders around complex scientific, operational, and business decisions; Experience developing and managing integrated program plans, timelines, decision frameworks, risk registers, dashboards, governance materials, and executive communications; Excellent communication, facilitation, problem-solving, conflict resolution, and stakeholder management skills, with the ability to distill complex information into clear recommendations; Highly organized, detail-oriented, and comfortable operating in a fast-paced, resource-constrained biotech environment with shifting priorities and high visibility deliverables; Experience with project management tools such as Smartsheet, Microsoft Project, Excel, PowerPoint, SharePoint, or similar platforms; Ability to travel occasionally for company meetings, team collaboration, external partner meetings, or industry events

Nice to have

Advanced degree such as MS, PhD, PharmD, MBA, or equivalent experience preferred; Experience supporting IND/CTA submissions and early clinical development preferred; Background in rare disease, cardiovascular disease, RNA therapeutics, oligonucleotides, targeted delivery platforms, or genetic medicines is a plus; Ability to lean into AI-enabled tools and ways of working to improve planning, communication, decision support, and operational efficiency

Benefits

Stock options and RSUs; 401(k) with employer match; Comprehensive wellness program including medical, dental, vision, LTD coverage; Unlimited time off including summer and winter breaks; Learning and development programming, job-specific training, and an education reimbursement program